Effects of glutathione S-transferase M1 and T1 deletions on Parkinson's disease risk among a North African population |
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| Authors: | A. Rebai C. Chbili S. Ben Amor A. Hassine S. Ben Ammou S. Saguem |
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| Affiliation: | 1. Metabolic Biophysics and Applied Pharmacology, Laboratory, Department of Biophysics, Faculty of Medicine Sousse, Sousse University, Sousse 4002, Tunisia;2. Faculty of Physical and Natural Mathematical Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia;3. Neurology Department of the University Hospital Center (UHC) Sahloul, Sousse University, Sousse 4002, Tunisia;1. Department of clinical and chemical pathology, faculty of medicine, Cairo university, 1, Al-Saray street, El Manial, 11562 Cairo, Egypt;2. Neurology department, faculty of medicine, Kasr Al Ainy hospital, Cairo university, Cairo, Egypt;3. Rashid hospital, Dubai, United Arab Emirates;1. Service de neurologie, hôpital Laënnec, CHU de Nantes, Nantes, France;2. Centre d’évaluation et de traitement de la douleur, FHU INOVPAIN, hôpital de La Timone, Marseille, France;1. Maison-Blanche hospital, Neurology department, Reims, France;2. Memory, Brain and Cognition (MC2Lab, EA 7536), Paris Descartes university, Boulogne-Billancourt, France;3. Sorbonne university, Paris, France;1. Service de neurologie, centre de référence neurogénétique, centre expert Parkinson, hôpitaux universitaires de Strasbourg, Strasbourg, France;2. Inserm-U964/CNRS-UMR7104/, institut de génétique et de biologie moléculaire et cellulaire (IGBMC), université de Strasbourg, Illkirch, France;3. Fédération de médecine translationnelle de Strasbourg (FMTS), université de Strasbourg, Strasbourg, France;1. AOR San Carlo, Neurology Department, Potenza, Italy;2. Alto Vicentino Hospital - AULSS, Neurology Department, 7, Pedemontana, Santorso, Italy;3. SS. Annunziata Hospital, Complex Structure of Neurology, Taranto, Italy;4. Palliative care and Pain management Department, ASST Valtellina, Sondrio, Italy;5. Magna Græcia University, Institute of Neurology Department of Medical and Surgical Sciences, Catanzaro, Italy |
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| Abstract: | PurposeIn this study, the effects of glutathione S-transferase polymorphisms Mu1 (GSTM1) and glutathione S-transferase polymorphisms Theta1 (GSTT1) on Parkinson's disease (PD) risk factor were evaluated in a Tunisian population.MethodsThese polymorphisms were analyzed in 229 healthy Tunisian subjects and 64 Tunisian patients with PD, using a polymerase chain reaction (PCR). Statistical analysis was performed using SPSS 18.0. The relative associations between the GST genotypes and PD were assessed by calculating the odds ratios (ORs) and 95% confidence intervals (CIs).ResultsThe study results demonstrated that the individuals with GSTM1 [OR = 3.93, 95% CI: 1.98–7.92, P = 10?6] and GSTT1 [OR = 5.45, 95% CI: 2.90–10.30, p = 10?6] were statistically associated with the risk of PD. A significant association was also found between the individuals with both GSTM1/T1 null genotypes and PD risk [OR = 22.10, 95% CI: 6.99–73.75, P = 10?6].ConclusionThese genotyping findings suggest that the absence of both GSTM1 and GSTT1 activity could be a contributory factor for the development of PD. |
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| Keywords: | Genetic polymorphisms Glutathione S-transferase M1 Glutathione S-transferase T1 Parkinson's disease |
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