Diaphragm ultrasound in the diagnosis of respiratory dysfunction in patients with amyotrophic lateral sclerosis |
| |
| Authors: | Q. Wen J. Ma X. Pang S. Huang J. Zhang J. Wang X. Chang J. Guo W. Zhang |
| |
| Affiliation: | 1. Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran;2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;3. Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;1. Université Côte d’Azur (UCA), Service de Rhumatologie, CHU de Nice, hôpital pasteur 2, 30, voie Romaine, CS 51069, 06001 Nice Cedex 1, France;2. Department of Rheumatology, FHU ACRONIM, CHU Pellegrin, Bordeaux, France;3. UMR E-4320 MATOs CEA/iBEB/SBTN, Université Nice Sophia Antipolis, Faculté de Médecine, 28, avenue de Valombrose, 06107 Nice Cedex 2, France;1. Department of Neurology, Grenoble-Alpes University Hospital, CS 10217, 38043 Grenoble, France;2. University Grenoble-Alpes, 38042 Grenoble, France;3. Department of Parasitology, Grenoble-Alpes University Hospital, 38043 Grenoble, France;1. Clinique Neurologique, Centre Hospitalier National Universitaire de Fann, BP 5035, Dakar, Senegal;2. UFR des Sciences de la Santé, Université de Thiès, Thiès, Senegal;3. St. George''s University School of Medicine, Grenada, West Indies, Grenade;1. Neurology Department, Ibn Rochd Hospital, Casablanca, Morocco;2. Genetics and Molecular Biology Laboratory, Faculty of Medicine, Hassan II University, 67, rue AbouAllaa Zahr, No. 20, Casablanca, Morocco |
| |
| Abstract: | ObjectiveIn this study, we aimed to select the best diaphragm ultrasonography (DUS) parameter as an alternative index for the diagnosis of lung function impairment in amyotrophic lateral sclerosis (ALS).MethodsTwenty-nine patients with ALS and 15 healthy subjects were enrolled in the study. DUS, lung function tests, phrenic nerve conduction study and arterial blood gas analysis were performed.ResultsPatients with respiratory dysfunction had a significantly lower level of ΔTmax than those without (P = 0.039). Significant correlations (P < 0.05) were found between forced vital capacity (FVC) and Tdi-ins (r = 0.665, P < 0.0001) and ΔTmax (r = ?0.748, P < 0.0001) and Δins-exp (r = 0.627, P < 0.0001) and ΔTdi (r = 0.485, P < 0.0001). Receiver Operating Curves analysis demonstrated that ΔTmax (AUC = 0.76, P = 0.044) had a better overall accuracy for detection of respiratory dysfunction compared with Tdi-ins (AUC = 0.27, P = 0.067), Δins-exp (AUC = 0.312, P = 0.139), and ΔTdi (AUC = 0.38, P = 0.359).ConclusionΔTmax is the most valuable DUS index in the diagnosis of diaphragmatic dysfunction.SignificanceDUS can provide functional and structural information of diaphragm and help to diagnose diaphragmatic dysfunction in ALS. |
| |
| Keywords: | Amyotrophic lateral sclerosis Diaphragmatic ultrasonography Pulmonary function tests Phrenic nerve conduction |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
