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Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort

Authors:	Paola Nicoletti Daniel F. Carr Sarah Barrett Laurence McEvoy Peter S. Friedmann Neil H. Shear Matthew R. Nelson Anca M. Chiriac Natalia Blanca-López José A. Cornejo-García Francesco Gaeta Alla Nakonechna Maria J. Torres Cristiano Caruso Rocco L. Valluzzi Aris Floratos Yufeng Shen Rebecca K. Pavlos Munir Pirmohamed

Affiliation:	1. Icahn School of Medicine at Mount Sinai, New York, NY;2. Sema4, Stamford, Conn;3. Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom;4. Dermatology Unit, Sir Henry Wellcome Research Laboratories, School of Medicine, University of Southampton, Southampton, United Kingdom;5. Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada;6. Deerfield, New York, NY;7. Division of Allergy, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France;8. Infanta Leonor University Hospital, Madrid, Spain;9. Allergy Research Group, Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA, ARADyAL, Malaga, Spain;10. Allergy Unit, Columbus Hospital, Fondazione Policlinico Universitario Agostino Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy;11. Liverpool University Hospitals Foundation National Health Service Trust, Liverpool, United Kingdom;12. Allergy Unit, Hospital Regional Universitario de Málaga, Malaga, Spain;13. Division of Allergy, University Department of Pediatrics, Pediatric Hospital Bambino Gesù, Rome, Italy;14. Department of Systems Biology, New York, NY;15. Department of Biomedical Informatics, Columbia University, New York, NY;p. Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, Australia;q. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn;r. Centre for Clinical Pharmacology and Infectious Diseases, Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia;s. Unité Mixte de Recherche en Santé (UMR-S) 1136 Institut National de la Santé et de la Recherche Médicale–Sorbonne Université, Equipe Epidemiology of allergic and respiratory diseases (EPAR)– Louis d''Epidémiologie et de Santé Publique (IPLESP), Paris, France;t. Istituto di Ricovero e Cura a Carattere Scientifico Oasi Maria SS, Troina, Italy;u. Fondazione Mediterranea GB Morgagni, Catania, Italy;v. Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Abstract:

Keywords:	Type I hypersensitivity β-lactams penicillins cephalosporins allergy anaphylaxis pharmacogenomics BL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" β-Lactam OR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" Odds ratio QTL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" Quantitative trait loci SNP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" Single nucleotide polymorphism
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