Othello syndrome in Parkinson's disease: A diagnostic emergency of an underestimated condition |
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| Authors: | H. El Otmani S. sabiry S. Bellakhdar B. El Moutawakil M. Abdoh Rafai |
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| Affiliation: | 1. Neurology Department, Ibn Rochd Hospital, Casablanca, Morocco;2. Genetics and Molecular Biology Laboratory, Faculty of Medicine, Hassan II University, 67, rue AbouAllaa Zahr, No. 20, Casablanca, Morocco;1. Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran;2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;3. Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;1. Fédération des hôpitaux de polyhandicap et multihandicap hôpital San Salvadour, Assistance publique–Hôpitaux de Paris, Paris, France;2. EA 3279, self-perceived health assessment research unit, school of medicine, Aix-Marseille université, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France;3. Hôpital d’Hendaye, Assistance publique–Hôpitaux de Paris, Hendaye, France;4. Union générale caisse assurance maladie (UGECAM), Île-de-France, France;5. Comité d’études, d’éducation et de soins auprès des personnes polyhandicapées, Paris, France;6. UPMC, GRC ConCer-LD, service de neuropédiatrie – pathologie du développement, hôpital Trousseau, Sorbonne université, assistance publique–hôpitaux de Paris, Paris, France;7. Inserm U 1141, centre de référence des déficits intellectuels de causes rares, Paris, France;8. Service de polyhandicap pédiatrique, hôpital de La Roche-Guyon, Assistance publique–Hôpitaux de Paris, La Roche-Guyon, France;9. Assistance publique–Hôpitaux de Paris, Paris, France;1. Department of interventional Neuroradiology, Fondation Rotschild, Paris, France;2. Department of Diagnostic and Therapeutic Neuroradiology, Hôpital Foch, Suresnes, France;1. NEuroMuscular Omnicentre, Fondazione Serena Onlus, Piazza Ospedale Maggiore 3, 20162 Milano, Italy;2. Neurorehabilitation Unit, University of Milan, Milan, Italy |
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| Abstract: | Othello syndrome (OS) is a type of delusional jealousy, characterized by the false absolute certainty of the infidelity of a partner. This syndrome is not uncommon in Parkinson's Disease (PD), appearing as side effect of Dopaminergic Agonists (DA) therapy. We analyze the observations of five patients with OS, diagnosed in a series of 250 consecutive PD patients during two years. All patients are men, with a particularly young age at onset of PD. The mean duration of DA therapy at OS onset was 3 years. One patient had hypersexuality and another had punding. Significant cognitive impairment was present in two patients. All patients were treated with DA: two with Pramipexol and three with Piribedil. At the time of the management of the OS, three patients had already divorced their spouse. It is imperative for clinicians to know this underestimated syndrome in order to identify it early and approach it adequately to avoid irreversible negative prejudice. |
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| Keywords: | Othello syndrome Delusional Jealousy Parkinson's disease |
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