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Regulating T-cell differentiation through the polyamine spermidine
Authors:Guilhermina M. Carriche  Luís Almeida  Philipp Stüve  Lis Velasquez  Ayesha Dhillon-LaBrooy  Urmi Roy  Marc Lindenberg  Till Strowig  Carlos Plaza-Sirvent  Ingo Schmitz  Matthias Lochner  Anna Katharina Simon  Tim Sparwasser
Affiliation:1. Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany;2. Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany;3. Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany;4. Hannover Medical School, Hannover, Germany;5. Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany;6. Systems-Oriented Immunology and Inflammation Research Group, Department of Experimental Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany;7. Department of Molecular Immunology, Ruhr-University Bochum, Bochum, Germany;8. Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany;9. Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom
Abstract:
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  • Keywords:Polyamines  spermidine  gut immunity  Treg cells  Atg"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Autophagy related  DC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0050"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Dendritic cell  FACS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0060"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Fluorescence-activated cell sorting  GC-MS/MS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0070"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Gas chromatography–tandem mass spectrometry  IBD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0080"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Inflammatory bowel disease  IMDM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0090"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Iscove modified Dulbecco medium  iTreg"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0100"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Induced regulatory T  MLN"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0110"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Mesenteric lymph node  mTor"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0120"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Mechanistic target of rapamycin kinase  ODC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0130"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Ornithine decarboxylase  SFB"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0140"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Segmented filamentous bacterium  SMO"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0150"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Spermine oxidase  Teff"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0160"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Effector T  Treg"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0170"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Regulatory T  WT"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0180"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Wild-type
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