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Stabilization of hypoxia-inducible factor ameliorates glomerular injury sensitization after tubulointerstitial injury
Authors:Jun Zou  Jaewon Yang  Xiaoye Zhu  Jianyong Zhong  Ahmed Elshaer  Taiji Matsusaka  Ira Pastan  Volker H Haase  Hai-Chun Yang  Agnes B Fogo
Institution:1. Division of Nephrology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;2. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA;3. Division of Nephrology, Yonsei University Wonju College of Medicine, Wonju, Gangwon, South Korea;4. Division of Nephrology, Huashan Hospital, Wudan University, Shanghai, China;5. Division of Pediatric Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee, USA;6. Institute of Medical Science, Tokai University, Isehara, Japan;7. Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA;8. Departments of Medicine, Cancer Biology, and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA;9. Medicine and Research Services, Department of Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee, USA;1. Sorbonne Université, Université Pierre et Marie Curie Paris 06, Paris, France;2. Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S1155, Paris, France;3. Division of Nephrology, Department of Internal Medicine Specialties, University Hospital of Geneva, Geneva, Switzerland;4. Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, France;5. Functional Genomics of Solid Tumor, Labex Immuno-Oncology, Equipe Labellisée Ligue Contre le Cancer, Université Paris 13, Paris, France;6. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA;7. Inserm U1151, Necker-Enfants Malades Hospital, Paris, France;8. University Paris Descartes, Sorbonne Paris Cité, Paris, France;9. Department of Adult Nephrology and Transplantation, Necker-Enfants Malades Hospital, Paris, France;10. Department of Nephrology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands;11. Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK;12. Department of Nephrology and Transplantation, University Hospital, Dijon, France;13. BioSpec T Laboratory, EA 7506 URCA, Reims, France;14. Nephropathology Department of Biopathology Laboratory, Reims University Hospital, Reims, France;15. Division of Nephrology, Reims University Hospital, Reims, France;16. Department of Laboratory Medicine and Pathology, Personalized Genomics Laboratory Mayo Clinic, Rochester, Minnesota, USA;17. IntegraGen, Evry, France;18. Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic;19. Department of Transplantation, Nephrology, and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France;20. Laboratoire HLA, Etablissement Français du Sang Auvergne Rhone-Alpes, Lyon, France;21. Nephrology Department, Hospital Universitari Bellvitge, Bellvitge Research Institute (IDIBELL), Barcelona, Spain;22. RedInRen, RD16/0009/0031, University of Barcelona, L’Hospitalet de Llobregat, Barcelona, Spain;23. Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, Tenerife, Spain;24. Division of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota, USA;25. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic;26. Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic;27. Department of Nephrology, University Hospital, Nantes, France;28. Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S 1109, Strasbourg University, Strasbourg, France;29. Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France;30. Department of Nephrology, Strasbourg University Hospital, Strasbourg, France;31. Université de Reims Champagne-Ardenne, CNRS UMR 7369 (Matrice Extracellulaire et Dynamique Cellulaire, MEDyC), Reims, France;32. Department of Nephrology, University Hospital, Amiens, France;33. Department of Nephrology, Fundación Puigvert, Barcelona, Spain;34. Department of Nephrology (Day Hospital), AP-HP, Tenon Hospital, Paris, France;1. Department of Biomedicine, Anatomy, Aarhus University, Aarhus, Denmark;1. Division of Nephrology, Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA;1. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA;2. Department of Perinatology, Olmsted Medical Center, Rochester, Minnesota, USA;3. Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA;4. QUEST – Quality | Ethics | Open Science | Translation, Charité – Universitätsmedizin Berlin, Berlin Institute of Health (BIH), Berlin, Germany;5. Department for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia;6. Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA;7. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA;8. Robert and Arlene Kogod Center on Aging, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA;9. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA;10. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA;1. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore;2. Centre for Public Health, Queen’s University Belfast, Belfast, Northern Ireland, UK;3. Department of Advanced Cancer Science, Yamagata University, Yamagata, Japan;4. Department of Ophthalmology, Yamagata University, Yamagata, Japan;5. William B. Schwartz Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA;6. Division of Nephrology, Department of Medicine, San Francisco VA Medical Center, San Francisco, California, USA;7. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA;8. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands;9. Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, the Netherlands;10. Centre for Vision Research, Department of Ophthalmology, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia;11. Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA;1. Inserm Unit 1018, Team 5, CESP, Hôpital Paul Brousse, Paris-Sud University and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France
Abstract:
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  • Keywords:dimethyloxalylglycine  glomerulosclerosis  HIF  interstitial fibrosis
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