A Novel Polyurethane Expandable Root Canal Sealer |
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Authors: | Mohammad Ali Saghiri Kasra Karamifar Devyani Nath James L Gutmann Nader Sheibani |
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Institution: | 1. Biomaterial and Prosthodontics Laboratory, Rutgers School of Dental Medicine, Newark, New Jersey;2. Department of Restorative Dentistry, Rutgers School of Dental Medicine, Newark, New Jersey;3. Department of Endodontics, University of the Pacific, Arthur A. Dugoni School of Dentistry, San Francisco, California;4. Sector of Angiogenesis Regenerative Medicine, Dr. Hajar Afsar Lajevardi Research Cluster, Hackensack, New Jersey;6. Department of Endodontics, Nova Southeastern University, College of Dental Medicine, Fort Lauderdale, Florida;5. McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;7. Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin |
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Abstract: | IntroductionEndodontic sealers play a vital role in the obturation of root canal space. The aim of this study was to evaluate the utility of a recently developed polyurethane expandable sealer (PES), along with its cytotoxicity and dimensional changes.MethodsL929 fibroblasts and an cell viability assay (MTS assay) were used to determine the cytotoxicity of dental sealers (AH Plus Dentsply Maillefer, Ballaigues, Switzerland], Sure-Seal Root Sure Dent Corporation, Gyeonggi-do, South Korea], and the PES) at 24, 48, 72, and 96 hours. An advanced choroidal neovascularization model was used to assess the effect of these sealers on angiogenesis. Thirty-six extracted single-rooted human teeth were prepared and randomly divided into 3 groups (n = 12). Obturation was performed with gutta-percha and a sealer using lateral compaction as follows: group 1, AH Plus; group 2, Sure-Seal; and group 3, PES. The average depth of sealer penetration into dentinal tubules was measured with a scanning electron microscope. Data were analyzed using 1-way analysis of variance and post hoc Tukey tests (level of significance, P < .05).ResultsThe values of MTS, choroidal neovascularization, and the penetration depth of PES were significantly higher than in other experimental groups (P < .05). The lowest values were noted in specimens of AH Plus, whereas the highest were detected in the PES group.ConclusionsPES showed promising results in terms of biocompatibility and dentinal tubule adaptation and penetration. |
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Keywords: | Angiogenesis factor biocompatibility testing canal sealer cytotoxicity test dentinal tubule penetration |
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