盐酸戊乙奎醚作为肝功能不全病人麻醉前用药的临床评价

目的：探讨盐酸戊乙奎醚作为麻醉前用药在肝功能不全患者中的有效性及安全性。方法：随机选择高强度聚焦超声技术治疗的原发性肝癌患者60例，30例为肝功能正常组（A组），30例为肝功能不全组（B组），麻醉前1小时肌肉注射盐酸戊乙奎醚1．0mg。结果：两组患者用药后心率、血压无显著变化，用药后日干明显高于用药前（P〈0．05）。B组日干持续时间长于A组（P〈0．01），术后复视发生率高于A组（P〈0．05）。结论：盐酸戊乙奎醚作为肝功能不全病人术前用药，其日干持续时间和复视率超过肝功能正常组。

The Clinical Evaluation of Penehyclidine Hydrochloride on Poor Liver Function Patients as Premedication

Objective: To evaluate the clinical effection of preoperative penehyclidine hydrochloride on poor liver function patients. Methods: Sixty liver cancer patients treated with High Intensity Focused Ultrasound(HTFU) were assigned to two groups: A group (n = 30) with normal liver function and B group (n = 30) with poor liver function. Penehyclidine hydrochloride 1. 0mg im was given an hour before introduction of anesthesia. Results: There were no significant difference in blood pressure and heart rate. VAS of thirst significant increase in two groups after Penehyclidine hydrochloride injection(P < 0.01) .The time of thirst of B group was long than that of A group(P < 0.05) ,and the cases of diplopia in B group was more than that in A group(P < 0.05) .Conclusion: The duration of thirstiness and the percent of diplopia exceed the normal liver function patients compared with penehyclidine hydrochloride on poor liver function patients as premedication.