Serological monitoring of protection of sheep against Echinococcus granulosus induced by the EG95 vaccine |
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Authors: | Heath D D Koolaard J |
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Institution: | Animal Health Division, AgResearch New Zealand Limited, Palmerston North, New Zealand. david.heath@agresearch.co.nz |
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Abstract: | Although immunity to Echinococcus granulosus in sheep has been shown to be antibody-mediated and complement-dependent and can be passively transferred in colostrum, in animals vaccinated with EG95, the relationship between protection against an oral challenge infection with E. granulosus eggs and anti-EG95 IgG ELISA absorbance values at the time of challenge has not been satisfactorily proven. Using a combination of results from three EG95 vaccination trials, we have found that the IgG ELISA absorbance at the time of challenge infection explains approximately 50% (P ≤ 0·001) of the variability in the percentage protection against an oral challenge with E. granulosus eggs (transformed with arcsin). |
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Keywords: | cystic echinococcosis Echinococcus granulosus EG95 vaccination hydatid serology sheep |
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