| 钙调素拮抗剂对大鼠脊髓损伤的作用及意义 |
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| 引用本文： | Zhang Y,Hou S,Liu R,Zhu Y,Liu Y. 钙调素拮抗剂对大鼠脊髓损伤的作用及意义[J]. 中华外科杂志, 1998, 36(12): 721-723 |
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| 作者姓名： | Zhang Y Hou S Liu R Zhu Y Liu Y |
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| 作者单位： | 解放军第三○四医院骨科第三军医大学外科研究所脊髓损伤研究室 |
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| 摘 要： | 目的观察钙调素（ＣａＭ）特异性拮抗剂三氟啦嗪（ＴＦＰ）对脊髓损伤（ＳＣＩ）的影响,探讨ＣａＭ在ＳＣＩ病理机制中的作用。方法采用氢清除法、斜板试验和电生理技术,以６４只大鼠为实验对象观察ＴＦＰ对ＳＣＩ后脊髓血流量（ＳＣＢＦ）、运动功能和诱发电位（ＭＥＰ）的影响。结果在肾上腺素维持系统动脉压的条件下,ＴＦＰ可明显改善ＳＣＩ后ＳＣＢＦ、ＭＥＰ和运动功能。结论ＣａＭ拮抗剂对ＳＣＩ具有保护作用,ＣａＭ可能是参与ＳＣＩ病理机制的重要因素
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| 关 键 词： | 脊髓损伤 三氟啦嗪 钙调素 |
Effect of calmodulin inhibitor on spinal cord injury |
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| Zhang Y,Hou S,Liu R,Zhu Y,Liu Y. Effect of calmodulin inhibitor on spinal cord injury[J]. Chinese Journal of Surgery, 1998, 36(12): 721-723 |
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| Authors: | Zhang Y Hou S Liu R Zhu Y Liu Y |
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| Affiliation: | Department of Orthopedics, 304th Hospital of Chenese People's Liberation Army, Beijing 100037. |
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| Abstract: | Objective To evaluate the effect of a special calmodulin (CaM) inhibitor trifluoperizine (TFP) on spinal cord injury (SCI) and the role of CaM in SCI. Method We observed the effect of TFP on spinal cord blood flow(SCBF), motor evoked potentials (MEP) and motor function in SCI by using hydrogen clearance,inclined plane and electro physiological technique. Result There was significant improvement of SCBF, MEP and motor function with TFP,when adrenaline mainteined the system arterial pressure in SCI. Conclusion Prevention by TFP of spinal cord function in SCI suggested that CaM plays a role in the pathogenesis of SCI. |
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| Keywords: | Spinal cord injuries Trifluoperizine Calmodulin |
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