| pim-3基因的分子生物学特性及作用 |
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| 引用本文： | 李小燕,朱水山,刘亮明,黄缘. pim-3基因的分子生物学特性及作用[J]. 医学分子生物学杂志, 2008, 5(2): 146-148. DOI: 10.3870/j.issn.1672-8009.2008.02.012 |
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| 作者姓名： | 李小燕 朱水山 刘亮明 黄缘 |
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| 作者单位： | 1. 南昌大学第二附属医院消化内科,南昌市,330006
2. 上海交通大学附属第一人民医院松江分院消化中心,上海市,200000 |
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| 摘 要： | Pim家族是一组编码丝/苏氨酸蛋白激酶的原癌基因,由pim-1、pim-2、pim-3组成。它们在人体不同组织器官中广泛分布,对其正常生长发育、分化、成熟起重要作用。Pim-3作为Pim家族的新成员,与Pim-1、Pim-2相似能磷酸化众多特异性底物,在细胞周期和细胞凋亡进程中起重要调控作用。同时,其在成体组织中的表达上调可导致某些恶性肿瘤的发生。
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| 关 键 词： | Pim-3 基因 细胞凋亡 恶性肿瘤 |
| 修稿时间： | 2007-10-16 |
Molecular Characterization and Biological Effects of the Pim-3 Gene |
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| LI Xiaoyan,ZHU Shuishan,LIU Liangming,HUANG Yuan. Molecular Characterization and Biological Effects of the Pim-3 Gene[J]. Journal of Medical Molecular Biology, 2008, 5(2): 146-148. DOI: 10.3870/j.issn.1672-8009.2008.02.012 |
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| Authors: | LI Xiaoyan ZHU Shuishan LIU Liangming HUANG Yuan |
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| Abstract: | The Pim family is a group of oncogenes which encode the serine/threonine protein kinase. It is composed of Pim-1, Pim-2 and Pim-3. They are extensively distributed in different tissues and organs, and play important roles in the growth, development of the body and cell differentiation. Pim-3, a new member of the family, can regulate the cell cycle, apoptosis and carciongenesis by phosphorylating specific substrates. Meanwhile, the upregulation of the Pim-3 gene can lead to the occurrence of the malignant tumors. This article reviews the recent advances in the research of Pim-3 gene. |
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| Keywords: | Pim-3 gene cell apoptosis malignant tumors |
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