| CD4~+CD25~+FOXP3~+调节性T细胞及其亚型在结直肠癌组织中分布和临床意义的研究 |
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| 引用本文： | 盖晓东,赵丽微,历春. CD4~+CD25~+FOXP3~+调节性T细胞及其亚型在结直肠癌组织中分布和临床意义的研究[J]. 中国免疫学杂志, 2010, 26(1) |
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| 作者姓名： | 盖晓东 赵丽微 历春 |
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| 作者单位： | 北华大学基础医学院病理解剖教研室,吉林,132013 |
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| 摘 要： | 目的:探讨CD4~+Cff25~+FOXP3~+调节性T细胞(Treg)及其亚型在结直肠癌组织(colorectal carcinoma,CRC)的分布和临床病理特征的关系.方法:收集42例CRC新鲜手术标本,应用冰冻切片、免疫组织化学SP法检测肿瘤组织和癌旁组织中FOXP3~+阳性细胞数,分析其与临床病理特征的相关性;应用双重免疫组化检测FOXP3和ICOS表达,分析FOXP3~+ICOS~+Treg和FOXP3~+ICOS-Treg两种细胞亚型分布情况.结果:CRC患者肿瘤组织中FOXP3分布显著多于癌旁组织,差异显著(P＜0.001);中低分化组Treg细胞数明显高于高分化组(P＜0.01);淋巴结转移组Treg细胞数明显高于无淋巴结转移组(P＜0.05);无远处转移组Treg细胞数明显高于有远处转移组(P＜0.05);FOXP3+ICOS+Treg细胞亚群在CRC组织中高表达,与癌旁组织相比差异显著(P＜0.01).结论:CRC的发生发展与其癌组织局部微环境中Treg数量变化相关,Treg在CRC组织过量表达可能是导致肿瘤免疫逃逸的重要因素之一;抑制CRC微环境中浸润性Treg细胞功能可提高肿瘤局部免疫治疗效果.
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| 关 键 词： | 结直肠癌 |
Distribution of CD4~+CD25~+FOXP3~+ regulatory T cells and their subsets in colorectal carcinoma and the clinical significance |
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| GAI Xiao-Dong,ZHAO Li-Wei,LI Chun. Distribution of CD4~+CD25~+FOXP3~+ regulatory T cells and their subsets in colorectal carcinoma and the clinical significance[J]. Chinese Journal of Immunology, 2010, 26(1) |
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| Authors: | GAI Xiao-Dong ZHAO Li-Wei LI Chun |
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| Affiliation: | GAI Xiao-Dong,ZHAO Li-Wei,LI Chun.School of Basic Medical Sciences,Beihua University,Jilin 132013,China |
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| Abstract: | Objective:To determine the distribution of CD4+CD25+FOXP3+ regulatory T cells (Treg) and Treg subsets in human colorectal carcinoma microenvironment and to explore their correlation with conventional clinico-pathological features.Methods:Frozen sections and Immunohistochemistry (IHC) were used to detect FOXP3+ Treg in fresh specimen collected from 42 patients with colorectal carcinoma.The number of FOXP3+ Treg was evaluated in terms of its association with clinico-pathological feature in tumor and peri-canc... |
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| Keywords: | Treg FOXP3 ICOS Colorectal carcinoma Treg FOXP3 ICOS |
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