| 膀胱癌与端粒酶活性 |
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| 引用本文： | 陈戬,申吉泓,庞荣清,徐鸿毅. 膀胱癌与端粒酶活性[J]. 昆明医学院学报, 2002, 23(2): 90-92 |
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| 作者姓名： | 陈戬 申吉泓 庞荣清 徐鸿毅 |
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| 作者单位： | 1. 昆明医学院第二附属医院泌尿外科,昆明,650101
2. 成都军区昆明总医院医学实验科,昆明,650032 |
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| 基金项目： | 云南省卫生厅青年基金资助项目 (No .99Q0 36 ) |
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| 摘 要： | 目的：研究膀胱癌组织端粒酶活性及其与膀胱癌临床特征，预后的关系。方法：应用端粒酶PCRELISA法检测膀胱癌组织及正常膀胱粘膜组织的端粒酶活性。结果：端粒酶在50例膀胱癌组织中阳性率为82％（41／50），正常膀胱粘膜组织无端粒酶活性表达，端粒酶活性与膀胱癌的初，复发有相关性（P＝0．028），结论：端粒酶可作为检测膀胱癌的一个敏感指标。
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| 关 键 词： | 膀胱癌 端粒酶 活性 PCRELISA |
| 文章编号： | 1003-4706(2002)02-090-03 |
| 修稿时间： | 2001-12-25 |
Bladder Carcinoma and Telomerase Activity |
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| CHEN Jin,SHEN Ji-hong,PANG Rong-qing,XU Hong-yi. Bladder Carcinoma and Telomerase Activity[J]. Journal of Kunming Medical College, 2002, 23(2): 90-92 |
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| Authors: | CHEN Jin SHEN Ji-hong PANG Rong-qing XU Hong-yi |
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| Abstract: | To investigate the relationship of telomerase activity with clinical features and prognosis in bladder carcinoma. Methods: Telomerase repeat amplification protocol-PCR-ELISA were used to detect telomerase activity in normal bladder mucosa and bladder carcinoma. Results: It was found that the positive rate of telomerase activity of bladder carcinoma was 82%(41/50), while telomerase activity expression in normal bladder mucosa was not found. Conclusion: Telomerase was a sensitive index in detecting bladder carcinoma. |
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| Keywords: | Bladder carcinoma Telomerase PCR-ELISA |
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