胃舒康胶囊对实验性胃溃疡的基础研究

目的探讨胃舒康胶囊(WSK)对实验性胃溃疡的作用及机制。方法采用大鼠利血平型胃溃疡、大鼠幽门结扎型胃溃疡和小鼠扭体法镇痛实验测定大鼠溃疡指数、溃疡抑制率、胃液分泌量、小鼠扭体次数及扭体潜伏期。结果WSK组溃疡指数、胃液分泌量、扭体次数及扭体潜伏期明显降低,而溃疡抑制率明显升高,与模型组比较均有显著性差异(P<0.05)。结论WSK对实验性胃溃疡有促进溃疡愈合,保护胃黏膜的作用,其机制与WSK活血化瘀、理气止痛、收敛制酸、健胃消食等作用有关。

Basic study on Weishukang capsule to experimental gastric ulcer

OBJECTIVE To study the pharmacodynamic function and mechanism of weishukang(WSK) capsule to experimental gastric ulcer.METHODS The index of rat's ulcer,the inhibiting rate,the gastric secretion of rat's stomach and the time of mice's wrenching body as well as its laten period were assayed by rats' gastric ulcer induced by reserpine and by ligating phlorus as well as analgesic experiment through mice's wrenching body. RESULTS The index of rat's ulcer,the gastric secretion,the time of mice's wrenching body and its latent period of WSK group were obviously decreased while the inhibiting rate of ulcer was obviously increased.Compared with the contrasting group the difference is significant(P<0.05).CONCLUSION Weishukang has the function of hastening ulcer healing and protecting gastric mucosa to experimental ulcer,its mechanism is correlative with the function of WSK's promoting blood circulation and dispersing blood stasis,regulating vital energy and alleviating pain,astringing and inhibiting acid,strengthening the stomach and digestion.