| 渗透促进剂对荜茇提取物中胡椒碱体外经皮吸收的影响 |
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| 引用本文： | 王丽,郑妮,方亮,余红芳,刘晓秋.渗透促进剂对荜茇提取物中胡椒碱体外经皮吸收的影响[J].沈阳药科大学学报,2010,27(1):20-23. |
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| 作者姓名： | 王丽 郑妮 方亮 余红芳 刘晓秋 |
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| 作者单位： | 沈阳药科大学中药学院;沈阳药科大学药学院; |
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| 摘 要： | 目的研究荜茇提取物中的主要成分胡椒碱的透皮吸收特性,确定最佳促进剂及质量浓度。方法采用卧式双室扩散池,以离体大鼠皮肤作为渗透屏障,用HPLC法测定样品中胡椒碱的质量浓度。以稳态流量(Js)、增渗比(ER)及滞后时间(tlag)为指标考察渗透促进剂对荜茇提取物中胡椒碱体外经皮吸收的影响。结果当用质量分数为10%的N-甲基-2-吡咯烷酮时,胡椒碱的稳态渗透速率最高。结论N-甲基-2-吡咯烷酮为荜茇提取物中胡椒碱经皮给药有效的渗透促进剂。
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| 关 键 词： | 胡椒碱 荜茇提取物 经皮渗透 N-甲基-2-吡咯烷酮 |
| 收稿时间： | 2009-4-21 |
| 修稿时间： | 2009-6-21 |
Effects of penetration enhancers on the in vitro percutaneous absorption of piperine in Extractum Piperis Longi |
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| WANG Li,ZHENG Ni,FANG Liang,YU Hong-fang,LIU Xiao-qiu.Effects of penetration enhancers on the in vitro percutaneous absorption of piperine in Extractum Piperis Longi[J].Journal of Shenyang Pharmaceutical University,2010,27(1):20-23. |
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| Authors: | WANG Li ZHENG Ni FANG Liang YU Hong-fang LIU Xiao-qiu |
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| Institution: | WANG Li1,ZHENG Ni2,FANG Liang2,YU Hong-fang1,LIU Xiao-qiu1 (1.School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China,2.School of Pharmacy,China) |
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| Abstract: | Objective To investigate the effects of penetration enhancers on the percutaneous absorption of piperine in Extractum Piperis Longi and select the optimal concentration of enhancer.Methods 2-Chamber diffusion cells were adopted as the apparatus for in vitro skin permeation,excised rat abdominal skin as barrier.HPLC method was established to determine the content of piperine in receiver compartment.The steady-state fluxes(Js)and enhancement ratios(ER)were calculated for different penetration enhancers in com... |
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| Keywords: | piperine Extractum Piperis Longi transdermal delivery N-methyl-2-pyrrolidone |
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