| 心房颤动患者血小板活化及内皮功能异常 |
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| 引用本文： | 王晓艳,吴红玲,苏卓娃,杜冀辉,查文清,刘俊.心房颤动患者血小板活化及内皮功能异常[J].中国药物与临床,2003,3(5):387-388. |
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| 作者姓名： | 王晓艳 吴红玲 苏卓娃 杜冀辉 查文清 刘俊 |
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| 作者单位： | 深圳市南山区人民医院心血管内科,518052 |
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| 摘 要： | 目的 研究心房颤动 (房颤 )患者血小板活化和内皮功能 ,探讨其临床意义。方法 采用全血流式细胞术测定慢性心房颤动患者 4 0例和正常对照组 30名血小板胞质内α 颗粒上的膜糖蛋白 (CD6 2p)、溶酶体膜糖蛋白 (CD6 3) ,用酶联免疫吸附实验测定血浆血管性血友病因子 (vonWillebrandfactor,vWF)。结果 房颤组血小板表面活性标志蛋白CD6 2 p( 8 8± 1 2 ) %、CD6 3( 3 0± 0 8) %和vWF( 15 2± 2 5 ) %均显著高于对照组 ( 3 3± 0 4 ) % ,( 1 5± 0 4 ) %和 ( 91± 13) % (P <0 0 1)。结论 房颤患者存在血小板活性增强和内皮功能异常 ,这些变化可能与房颤患者心房内血栓形成相关。
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| 关 键 词： | 心房颤动 血小板活化 内皮 |
| 修稿时间： | 2003年6月9日 |
Platelet activation and endothelial cell disturbance in patients with atrial fibrillation |
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| Abstract: | Objective To investigate platelet activation and endothelial cell disturbance in patients with atrial fibrillation and the clinical significance.Methods Platelet activation factor CD62p?CD63 were detected by flow cytometry and the plasma von Willebrand factor (vWF) was measured by ELISA in 40 patients with atrial fibrillation and 30 normal subjects. Results The levels of platelet activation factor CD62p,CD63 and vWF in patients with chronic atrial fibrillation were significantly higher than those in the normal subjects ( P <0 01).Conclusion Patients with atrial fibrillation show evidence of platelet activation and endothelial cell disturbance,which may correlate with the atrial thrombogenesis. |
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| Keywords: | Atrial fibrillation Platelet activation Endothelium |
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