P27及细胞周期素D1在子宫内膜癌中的表达及意义

目的探讨p27蛋白及细胞周期素D1(cyclinD1)在子宫内膜癌中的表达及意义。方法采用免疫组化SP法检测42例子宫内膜癌中p27蛋白及cyclinD1的表达。结果子宫内膜癌p27蛋白的核表达率为16.7%,明显低于对照组(正常子宫内膜及非典型增生子宫内膜),cyclinD1的核表达率为40.5%,明显高于对照组;p27和cyclinD1表达均与子宫内膜癌的细胞学分级及临床分期有关(P<0.05);p27核低表达合并cyclinD1阳性高表达出现在分化差及手术病理分期高的病例。结论p27蛋白核表达的降低及cy-clinD1蛋白核表达增高与子宫内膜癌的发生发展相关,联合检测p27、cyclinD1蛋白有助于估计预后,指导治疗。

Expression of p27 and CyclinD1 Protein in Endometrial Carcinoma and Its Clinical Significance

Objective To investigate the expression of p27 and cyclinD1 proteins in endometrial carcinoma and its clinical significance.Methods Immunohistochemical technique was used to detect the expressions of p27 and cyclinD1 protein in 42 cases of endometrial carcinoma.Result The nuclear expression rate of p27 protein in endometrial carcinoma was 16.7% and it was significantly lower than that in the control group (normal and hyperplasia endometrial),the nuclear expression rate of cyclinD1 protein in endometrial carcinoma was significantly higher than that in the control group. The nuclear expressions of p27 and cyclinD1 proteins had a relationship with cell difference and stage. The combination of low nuclear expression with high expression of cyclinD1 occurred more often in cases of higher histologixal grade and advanced stage. Conclusion Decreased nuclear expression of p27 and of endometrial cancer. Investigation of these two cell-cycle proteins may be helpful in estimating prognosis and directing therapy.