| 不同糖化血红蛋白水平的2型糖尿病患者下丘脑-垂体-肾上腺轴功能分析 |
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| 引用本文： | 周珺,张汝学,贾正平,罗晓红,姜一真,李静,邱建国,保芸. 不同糖化血红蛋白水平的2型糖尿病患者下丘脑-垂体-肾上腺轴功能分析[J]. 中华内分泌代谢杂志, 2011, 27(5). DOI: 10.3760/cma.j.issn.1000-6699.2011.05.008 |
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| 作者姓名： | 周珺 张汝学 贾正平 罗晓红 姜一真 李静 邱建国 保芸 |
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| 作者单位： | 1. 兰州军区兰州总医院药材科,730050
2. 兰州军区兰州总医院内分泌科,730050 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 研究不同HbA1C水平2型糖尿病患者的下丘脑-垂体-肾上腺(HPA)轴功能.发现HbA1C≤7%组HPA轴功能无亢进[ACTH(18.03±8.39)ng/L,血皮质醇(49.22±8.68)μg/L],7%11%组HPA轴功能持续性亢进使得其负反馈环路消失[ACTH(26.08±15.41)ng/L,血皮质醇(55.64±24.27)μg/L].提示糖代谢紊乱程度不同的2型糖尿病患者HPA轴功能及其影响因素不同.Abstract：Hypothalamic-pituitary-adrenal(HPA)axis-related factors in patients with type 2 diabetes were studied according to different levels of HbA1C.It showed that HPA axis was normal in HbA1C≤ 7% group[ACTH (18.03±8.39)ng/L,blood cortisol(49.22±8.68)μg/L],hyperactive in 7%11% group with weak feedback regulation[ACTH(26.08±15.41)ng/L,blood cortisol(55.64±24.27)μg/L].These results suggest that HPA axis-related factors in type 2 diabetic patients are different with different grades of glucose metabolic turbulence.
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| 关 键 词： | 下丘脑-垂体-肾上腺轴 糖尿病,2型 |
Analysis of hypothalamic-pituitary-adrenal axis function in type 2 diabetic patients with different levels of HbA1C |
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| ZHOU Jun,ZHANG Ru-xue,JIA Zheng-ping,LUO Xiao-hong,JIANG Yi-zhen,LI Jing,QIU Jian-ggo,BAO Yun. Analysis of hypothalamic-pituitary-adrenal axis function in type 2 diabetic patients with different levels of HbA1C[J]. Chinese Journal of Endocrinology and Metabolism, 2011, 27(5). DOI: 10.3760/cma.j.issn.1000-6699.2011.05.008 |
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| Authors: | ZHOU Jun ZHANG Ru-xue JIA Zheng-ping LUO Xiao-hong JIANG Yi-zhen LI Jing QIU Jian-ggo BAO Yun |
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| Abstract: | Hypothalamic-pituitary-adrenal(HPA)axis-related factors in patients with type 2 diabetes were studied according to different levels of HbA1C.It showed that HPA axis was normal in HbA1C≤ 7% group[ACTH (18.03±8.39)ng/L,blood cortisol(49.22±8.68)μg/L],hyperactive in 7%11% group with weak feedback regulation[ACTH(26.08±15.41)ng/L,blood cortisol(55.64±24.27)μg/L].These results suggest that HPA axis-related factors in type 2 diabetic patients are different with different grades of glucose metabolic turbulence. |
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| Keywords: | HbA1C |
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