| 钩枝藤中生物碱的分离和鉴定 |
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| 引用本文： | 陈政雄,王保德,秦国伟,张宝恩,苏绮兰,林启超. 钩枝藤中生物碱的分离和鉴定[J]. 药学学报, 1981, 16(7): 519-523 |
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| 作者姓名： | 陈政雄 王保德 秦国伟 张宝恩 苏绮兰 林启超 |
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| 作者单位： | 中国科学院上海药物研究所(陈政雄，王保德，秦国伟)，广州市医药工业研究所(张宝恩，苏绮兰)，广州市医药工业研究所(林启超) |
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| 摘 要： | 钩枝藤(Ancistrocladus tectorius)的总生物碱对大白鼠W-256有一定的抑制作用,从中分得三种带有萘环的四氢异喹啉生物碱结晶,晶1和晶2分别鉴定为ancistrocladine(Ⅰ)和hamatine(Ⅱ),晶3为新生物碱,命名为钩枝藤碱(ancistrocline),并推定其平面结构和部分立体关系如(Ⅲ)所示,总生物碱,晶1和晶2对小鼠肿瘤S-180和艾氏腹水瘤的抑制作用不明显,其他抗肿瘤试验还在进行中。
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| 收稿时间： | 1980-04-28 |
ISOLATION AND IDENTIFICATION OF THE ALKALOIDS FROM ANCISTROCLADUS TECTORIUS |
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| Chen Zhengxiong,Wang Baode and Qin Kuowei Zhang Baoen,Su Qilan and Lin Qichao. ISOLATION AND IDENTIFICATION OF THE ALKALOIDS FROM ANCISTROCLADUS TECTORIUS[J]. Acta pharmaceutica Sinica, 1981, 16(7): 519-523 |
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| Authors: | Chen Zhengxiong Wang Baode Qin Kuowei Zhang Baoen Su Qilan Lin Qichao |
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| Abstract: | The crude alkaloid extracted from the stems and twigs of Ancistrocladus tectorius (Ancistrocladaceae) was found to have inhibiting effect on Walker 256 tumor in rats. Two known alkaloids were separated and identified as ancistrocladine (Ⅰ) and hamatine (Ⅱ). Besides, a new alkaloid named ancistrocline (Ⅲ), C26 H31 NO4, mp 227-228℃, [α]D33.5+61.7 (CHCl3), was separated and proved to be 5-(4, 5-dimethoxy-2-methyl-naphthyl)-1, 2, 3, 4-tetrahydro-6-hydroxy-8-methoxy-1, 3-dimethyl isoquinoline by spectral analysis. According to NMR spectral analysis, the CH3 groups 1-and 3-positions of ancistrocline (Ⅲ) are equatorial. |
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