Anti-inflammatory activity of Terminalia paniculata bark extract against acute and chronic inflammation in rats |
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Authors: | Talwar Sahil Nandakumar K Nayak Pawan G Bansal Punit Mudgal Jayesh Mor Vijay Rao Chamallamudi Mallikarjuna Lobo Richard |
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Affiliation: | a Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576 104, India b Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576 104, India |
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Abstract: | Ethnopharmacological relevanceTerminalia paniculata Roxb. (Family-Combretaceae) is a wild tree commonly used in traditional ayurvedic medicine for the treatment of inflammation of parotid glands and in menstrual disorders.Aim of the studyTo explore the folk use of Terminalia paniculata on pharmacological grounds to evaluate the scientific basis of anti-inflammatory activity.Materials and methodsThe anti-inflammatory activity of Terminalia paniculata was studied against carrageenan-induced hind paw edema, air pouch inflammation and complete Freund's adjuvant (CFA)-induced arthritis in rats. The aqueous extract of Terminalia paniculata bark (TPW) was administered at the concentrations of 100, 200 and 400 mg/kg body weight.ResultsTPW showed significant (p < 0.05) anti-inflammatory activity by reducing the edema volume in carrageenan-induced paw edema in rats. Further, TPW (400 mg/kg) also reduced the carrageenan-induced leukocyte migration (50.92 ± 5.71%) and myeloperoxidase activity (49.31 ± 5.24%) in air pouch exudates. TPW (200 mg/kg) exhibits anti-rheumatic and analgesic activities by improving the altered haematological milieu (ESR, CRP, RF, WBC, RBC and Hb) and also by inhibiting the flexion scores and radiographic changes in CFA-induced arthritis. This extract also had significant (p < 0.05) effects on the occurrence of secondary lesions compared to CFA control.ConclusionsTerminalia paniculata bark may be a potential preventive or therapeutic candidate for the treatment of chronic inflammation and arthritis. |
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Keywords: | CFA, complete Freund's adjuvant CRP, C-reactive protein ESR, erythrocyte sedimentation rate Hb, haemoglobin MPO, myeloperoxidase PMNs, polymorphonuclear neutrophils RBC, red blood cell RF, rheumatoid factor TPW, aqueous extract of Terminalia paniculata bark WBC, white blood cell |
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