成纤维细胞生长因子对兔下颌牵张成骨的影响

目的 研究局部应用碱性成纤维细胞生长因子（bFGF)对兔下颌牵引张成骨的影响。方法 成年大耳白兔8只，随机分为A、B两组，每组4只。用自行研制的牵张器延长双侧下颌骨6mm，用bFGF（20ng/ml）注入A组动物的牵张区，不注射bFGF的B组动物作为对照。在牵张结束后4周处死所有动物，取双侧下颌骨标本进行X线和组织学检查。结果 组织学分析结果显示，局部给予bFGF的A组动物下颌牵张后新骨生成速度和数量优于B组动物。结论 外源性导入碱性成纤维细胞生长因了可能有促进下颌牵引张成骨的作用。

Effects of basic fibroblast growth factor on mandibular distraction osteogenesis in rabbits

Objective To study the effects of bFGF on new bone formation during mandibular distraction osteogenesis in rabbits. Methods 8 mature rabbits were randomly divided into group A (n=4) and group B (n=4). Bilateral mandibular osteotomies were performed and the mandibles of 8 rabbits were lengthened 6 mm using a custom made distractor. The group A rabbits were injected with bFGF solution (20 ng/ml) into the distracted region, whereas group B was used as controls. At 4 weeks after end of distraction, all animals were killed and the mandibles specimens were processed for histological analysis. Results The new bone formation of group A treated by bFGF was superior to that of group B after mandibular distraction. Conclusion bFGF appears to be able to accelerate bone formation during mandibular distraction osteogenesis.