轻度认知障碍和阿尔茨海默病患者血白细胞介素-6水平变化

目的观察轻度认知障碍（MCI）和阿尔茨海默病（AD）患者血清白细胞介素-6（IL-6）水平变化。方法采用双抗体夹心酶联免疫吸附试验（ELISA）法检测AD 14例、MCI 14例和对照组11例的血清IL-6水平。结果 3组血清IL-6水平比较差异有统计学意义（P〈0.05）,MCI组和AD组血清IL-6水平均高于对照组（P〈0.05）,MCI组与AD组相比差异无统计学意义（P〉0.05）。结论 MCI及AD均有炎症改变,提示炎症反应可能是AD发病机制中的一个重要环节,在AD进一步病理变化过程中可能起重要作用。

Changes of Serum IL-6 in Mild Cognitive Impairment and Alzheimer's Disease

Objective To observe the diversity of serum IL-6 in patients with mild cognitive impairment（MCI）and Alzheimer＇s disease（AD）.Methods The IL-6 content in serum of AD（n=14）、MCI（n=14）and controls（n=11）were detected by double-antibody sandwich method of enzyme linked immunosorbent assay（ELISA）.Results The difference of serum IL-6 among three groups was significant（P〈0.05）.the serum IL-6 in MCI group and AD group were significant higher than that of the controls（P〈0.05）.No significant difference between was found between MCI group and AD group（P〉0.05）.Conclusion There is inflammation change in both MCI and AD patients,suggesting inflammatory reaction is a possible key component element of the pathological mechanism of AD,and possibly make important effect on further pathological development of AD.