CD1c antigens are present in normal and neoplastic B-cells |
| |
| Authors: | M E Smith J A Thomas W F Bodmer |
| |
| Institution: | Histopathology Unit, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, U.K. |
| |
| Abstract: | The immunohistochemical detection of CD1c antigen is described in mantle zone B-cells of the tonsil, lymph node, and spleen, and also in the marginal zone B-cells of the spleen. CD1c expression was observed in most cases of low-grade, but in only a single case of high-grade, B-cell non-Hodgkin's lymphoma. It was not detected in germinal centre cells, nor in Epstein-Barr virus-transformed or Burkitt's lymphoma B-cell lines. This distribution suggests that CD1c expression may occur preferentially in slowly proliferating B-cell populations and does not support previous suggestions that CD1c is a human equivalent of the mouse thymus leukaemia antigens. |
| |
| Keywords: | CD1 antigens B-lymphocytes B-cell non-Hodgkin's lymphoma |
|
|
