| 血清VEGF水平与冠状动脉病变程度的临床研究 |
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| 引用本文： | 孙林,张戈,白文伟,楚天舒.血清VEGF水平与冠状动脉病变程度的临床研究[J].心脑血管病防治,2010,10(4):257-258. |
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| 作者姓名： | 孙林 张戈 白文伟 楚天舒 |
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| 作者单位： | 昆明医学院第二附属医院心血管内科,云南,昆明,650101 |
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| 基金项目： | 云南省教育厅科研基金资助项目 |
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| 摘 要： | 冠心病严重威胁着人类的健康，国内外研究证实血管内皮细胞生长因子（vascular endothelial growth factor，VEGF）及碱性成纤维细胞生长因子（basic fibroblast growth factor，bFGF）有强烈的促血管新生作用，能促进缺血心肌侧枝血管明显增加，在冠心病的治疗方面有广阔的临床应用前景。
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| 关 键 词： | 冠状动脉病变程度 血清VEGF 血管内皮细胞生长因子 临床研究 碱性成纤维细胞生长因子 促血管新生 缺血心肌 临床应用 |
The Correlation between Serum Level of Vascular Endothelial Growth Factor and Severity of Coronary Artery Stenosis |
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| Institution: | SUN Lin,ZHANG Ge,BAI Wen-wei,et al.(Department of cardiology,the 2nd Affiliated Hospital of Kunming Medical College,Yunnan 650101,China ) |
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| Abstract: | Objective To study the correlation between serum level of vascular endothelial growth factor（VEGF） and severity of coronary artery stenosis.Methods This study included 114 patients with coronary haert disease（CHD group） and 92 hearthy people（control group）.The serum VEGF level was measured by ABC-ELISA in all cases and was compared with the severity of coronary artery stenosis.Results The level of VEGF in CHD group was significantly higher than that in control group（141.17±19.94pg/ml Vs 17.73±6.45pg/ml,P〈0.01）.The serum VEGF level in 2 or 3 coronary branches lesions subgroups was 129.52±19.87 pg/ml and 158.25±26.77pg/ml,respectively,which were significantly higher than that in single branch lesion subgroup（100.79±17.81pg/ml,P〈0.01）.Conclusions The serum VEGF level could reflect the severity of coronary artery stenosis. |
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| Keywords: | VEGF |
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