DECREASED RENAL RESPONSES TO ATRIAL NATRIURETIC PEPTIDE IN RENAL WRAP HYPERTENSION |
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| Authors: | M. Takata K. M. Denton R. L. Woods W. P. Anderson |
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| Affiliation: | Emily E. E. Stewart Renal Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia. |
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| Abstract: | 1. The effects of atrial natriuretic polypeptide (ANP) on renal function were examined in renal wrap hypertensive rabbits and sham operated rabbits. 2. ANP (2 micrograms/min) induced hypotension, but did not produce significant diuresis, natriuresis or change in the glomerular filtration rate (GFR) in renal wrap hypertensive rabbits (n = 8). 3. In sham operated normotensive rabbits (n = 4), ANP induced significant diuresis (230%) and increased GFR by about 40%. 4. Thus, ANP was markedly less effective in the impaired kidneys of renal wrapped rabbits than in normal kidneys. |
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| Keywords: | atrial natriuretic polypeptide, diuresis, glomeruler filtration rate, renal wrap hypertension, natriuresis. |
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