Fertilization and early embryology: Sexual differentiation and preimplantation cell growth |
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| Authors: | Pergament, E. Fiddler, M. Cho, N. Johnson, D. Holmgren, W.J. |
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| Affiliation: | 1Department of Obstetrics and Gynecology Northwestern Memorial Hospital Chicago, IL 60611, USA 2School for New Learning, DePaul University Chicago, IL 3Department of Medicine, Northwestern University Medical School Chicago, IL 4Department of Obstetrics and Gynecology, Northwestern Memorial Hospital Chicago, IL 60611, USA |
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| Abstract: | Growth rates of human preimplantation embryos fertilized invitro were assessed and compared to the sex of the pregnancyoutcome. The likelihood of a liveborn male was significantlygreater than that of a female if the mean number of cells/embryowas four or greater at the scheduled time of transfer (oddsratio of 6: 1). This finding suggested that the Y chromosomeexpresses factors which influence embryonic growth rates immediatelyafter fertilization. |
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| Keywords: | cell growth/preimplantation/sexual differentiation/Y chromosome |
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