Anion transport by human placenta: a study of chloride and sulphate efflux from isolated placental tissue fragments. |
| |
Authors: | D B Shennan |
| |
Affiliation: | Hannah Research Institute, Scotland, UK. |
| |
Abstract: | The efflux of radiolabelled sulphate and chloride from fragments prepared from normal human term placentae has been examined so that a comparison between the transport properties of whole tissue and isolated placental membranes may be made. Sulphate efflux was found via a temperature- and DIDS sensitive mechanism. External chloride and sulphate were able to trans-accelerate the egress of labelled sulphate from tissue fragments via a DIDS-inhibitable route. These results are consistent with sulphate transport being mediated via an anion-exchange process. Chloride efflux from fragments of placenta was via a system which could be trans-stimulated by external Cl-: this moiety of transport was inhibited by DIDS. Several differences between the characteristics of placental tissue anion transport and isolated membrane vesicles were noted and are discussed. |
| |
Keywords: | |
|
|