女贞叶乙醇提取物对鹌鹑高脂血症的影响

目的:观察女贞叶乙醇提取物对鹌鹑高脂血症的影响.方法:用外源性胆固醇和高脂饲料复制鹌鹑高脂血症模型,并诱发其肝脂肪变性,分为正常对照组、高脂模型组、脂必妥组(3 g·kg-1)、女贞叶乙醇提取物高、中、低组(1.5,3,6g·kg-1),给药4周.分别测定各组血清甘油三酯(TG)、胆固醇(CHO)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的含量,并进行鹌鹑肝脂肪变性的病理组织学检查.结果:女贞叶乙醇提取物低剂量能降低血清TG(P ＜0.05);中、高剂量能明显降低血清TG,CHO(P ＜0.01),中、高剂量降低血清LDL-C(P＜0.05,P＜0.01),高剂量组能明显升高血清HDLC(P＜0.01).给予女贞叶乙醇提取物后,鹌鹑肝系数明显减轻(P＜0.01),肝中脂肪空泡数明显减少(P＜0.01).结论:女贞叶乙醇提取物具有明显的防治鹌鹑高脂血症和肝脂肪变性的作用.

Effect of the Ethanol Extracts of Glossy Privet Leaf on Hyperlipemia Model of Quail

Objective: To observe the effect of the ethanol extracts of glossy privet leaf on hyperlipemia model of quail. Method: Hyperlipemia model of quail were induced by exogenous cholesterol and high fat diets until the liver's fatty degeneration, Quails were randomly divided into the normal group,the model group of high fatty,the zhibituo group (3 g·kg^-1),the high,middle and low dose group of ethanol extracts from glossy privet leaf (1.5,3,6 g·kg^-1), each group was administrated for according drug for 4 weeks. The serum content of triglyceride(TG) cholesterol(CHO),low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) of each group was determined after administration. Meanwhile, the histopathologic examination in livers fatty degeneration was also detected. Result: The low dose of the extracts of glossy privet leaf could decreased the level of TG in sevum (P<0.05), while the middle and high dose could significantly decreased the levels of CHO and TG in serum (P<0.01). High dose of extraction glossy privet leaf could significantly rise the level of HDL-C in serum while has counter effect on LDL-C. The coefficient of liver weight and the amount of hepatic fatty degeneration had been obviously reduced in both ethanol extract group (P<0.01). Conclusion: The ethanol extracts of glossy privet leaf have effects on preventing and treating the experimental hyperlipemia and liver's fatty degeneration of quail.