三七总皂苷脂质体微丸的制备

目的:制备三七总皂苷脂质体微丸.方法:以包封率为考察指标,大豆磷脂-胆固醇、水相-有机相,药物质量浓度,脂类用量为考察因素,通过正交设计优选三七总皂苷脂质体冻干粉的处方工艺,采用塑制法制备三七总皂苷脂质体微丸.结果:三七总皂苷脂质体冻干粉的最佳处方工艺为大豆磷脂-胆固醇(6∶1),水相-有机相(1∶4),药物质量浓度20 g·L-1,磷脂用量150 mg.制备的脂质体微丸溶解后脂质体的平均粒径220.5 nm,Zeta电位-71.21 mV,1h内溶出度达81.41％.结论:制备的三七总皂苷脂质体微丸体外溶出度较高,脂质体的粒径分布较好、质量稳定.

Preparation of Panax notoginseng Saponins Liposome Pellets

Objective: To prepare Panax notoginseng saponins liposome pellets. Method: With entrapment efficiency as index,orthogonal design was adopted to investigate effects of proportion of soybean phospholipid and cholesterol,ratio of water phase and organic phase,the concentration of drugs and lipid dosage on formulation technology of P notoginseng saponins liposome lyophilized powder,then P notoginseng saponins liposome pellets was prepared by plastic method. Result: Optional formulation technology of P notoginseng saponins liposome lyophilized powder were as follows:proportion of soybean phospholipid and cholesterol (6: 1),ratio of water phase and organic phase (1: 4),the concentration of drugs 20 g·L^-1,lipid dosage 150 mg.After dissolved of prepared liposome pellets,average particle size of liposomes was 220.5 nm,Zeta potential was-71.2 mv,dissolution was up to 81.41% within 1 h. Conclusion: Dissolution of prepared P notoginseng saponins liposome pellets was high,particle size distribution of liposomes was well and quality was stable.