凉血消风饮治疗HIV相关性痒疹的研究

目的:观察中药方剂凉血消风饮治疗艾滋病相关瘙痒性丘疹性皮疹(HIV-PPE)的临床疗效,并分析其对患者生存质量的影响.方法:用随机方法将符合纳入标准的63个病人分为治疗组(33例)和对照组(30例).治疗组采用糠酸莫米松霜联合凉血消风饮治疗,对照组采用糠酸莫米松霜治疗,疗程4周.分别使用HIV-PPE临床表现量化表、中医证候观察表、皮肤病生活质量指数(DLQI)和WHOQOL-HIV生存质量量表观察HIV-PPE病人的临床症状、中医证候和生活质量变化.结果:在改善皮肤临床症状方面:治疗组总有效率为90.9％,对照组总有效率76.67％.在改善中医证候方面:治疗组总有效率为96.97％,对照组总有效率83.33％.治疗前后两组患者DLQI积分变化分别是治疗组(9.35 +2.86,7.36±2.93),对照组(8.91±2.22,7.53±2.89).结论:凉血消风饮对HIV-PPE(血热生风型)有明确的治疗作用,能明显改善患者的临床症状、体征.

Study on Liangxue Xiaofeng Yin Treating HIV-Pruritic Popular Eruption

Objective: To observe the clinical effect of Liangxue Xiaofeng Yin on HIV-pruritic popular eruption(HIV-PPE),and the life quality of patients suffered from HIV-PPE. Method: Sixty-three patients were divided randomly into the test(33 cases)and the control(30 cases)according to diagnosis standard. The mometasone furoate cream and Liangxue Xiaofeng Yin was used in the test. Mometasone furoate cream was used in the control. Course of treatment was 4 weeks. The clinical symptoms,traditional Chinese medicine(TCM) symptoms and life quality of HIV-PPE were observed respectively by HIV-PPE clinical symptom scale,TCM symptom scale, DLQI and WHOQOL-HIV. Result: The total effective rate of dermatic clinical symptoms in the test and the control was 90.9% and 76.67%,respectively. The total effective rate of TCM symptoms in the test and the control was 96.97% and 83.33%, respectively. The change of DLQI before and after treatment was (9.35±2.86)and (7.36±2.93), respectively in the test, group, and(8.91±2.22),(7.53±2.89)in the control group. Conclusion: Liangxue Xiaofeng Yin has treating effects on HIV-PPE. The clinical symptoms and body signs of patients can be improved obviously.