| 雄黄肾脏毒性的病理形态学特征 |
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| 引用本文： | 高双荣,梁爱华,戴宝强,王丽芳,李桂琴,曹春雨,刘婷,李春英,易艳,王海林,郝然,赵雍,回连强,夏晶,曹帅,李丽敏,季申.雄黄肾脏毒性的病理形态学特征[J].中国实验方剂学杂志,2013,19(18):297-301. |
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| 作者姓名： | 高双荣 梁爱华 戴宝强 王丽芳 李桂琴 曹春雨 刘婷 李春英 易艳 王海林 郝然 赵雍 回连强 夏晶 曹帅 李丽敏 季申 |
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| 作者单位： | 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 国家自然科学基金项目(81001692);国家"十一五"科技支撑计划项目(2006BAI55B02-03);国家科技重大专项(2009ZX09301005);中国中医科学院自主选题项目(ZZ03046) |
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| 摘 要： | 目的:研究反复灌胃给予雄黄后,大鼠肾脏毒性的病理形态学特征,为临床安全、有效地使用雄黄提供科学依据.方法:随机将大鼠分为对照组和雄黄0.01,0.04,0.17 g·kg-1剂量组.各剂量组均每日灌胃给药1次,对照组给予高纯水,连续3个月.于给药后1,2,3个月和停药1,2个月后,计算肾脏指数,测定血清葡萄糖(GLU)、肌酐(Cr)、尿素氮(BUN)及尿蛋白等,并观察肾组织病理形态学变化.结果:连续灌服雄黄≥≥0.01 g·kg-13个月或0.17g·kg-1 2个月,肾组织出现不同程度的细胞肿胀,胞浆空泡变性,核固缩、溶解及血管扩张、充血等病变,近曲小管较肾小球损伤严重,病变呈现明显的量-时-毒关系,血BUN、GLU、尿蛋白也相应增高.停药1个月后,除0.17 g·kg-1剂量组有66.7％的肾小管轻度水肿、变性外,其余各组未见明显病变.结论:大鼠连续灌服雄黄≥0.01 g·kg-1 3个月或0.17 g·kg-1 2个月对大鼠肾脏病理学产生明显影响,尤其对肾脏近曲小管的损伤作用较为明显,停药后肾脏病变逐渐恢复至正常.
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| 关 键 词： | 雄黄 肾脏 毒性 病理 |
| 收稿时间： | 2013/4/11 0:00:00 |
Morphological Characteristics of Kidney Toxicity in Realgar |
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| GAO Shuang-rong,LIANG Ai-hu,DAI Bao-qiang,WANG Li-fang,LI Gui-qin,CAO Chun-yu,LIU Ting,LI Chun-ying,YI Yan,WANG Hai-lin,HAO Ran,ZHAO Yong,HUI Lian-qiang,XIA Jing,CAO Shuai,LI Li-min and JI Shen.Morphological Characteristics of Kidney Toxicity in Realgar[J].China Journal of Experimental Traditional Medical Formulae,2013,19(18):297-301. |
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| Authors: | GAO Shuang-rong LIANG Ai-hu DAI Bao-qiang WANG Li-fang LI Gui-qin CAO Chun-yu LIU Ting LI Chun-ying YI Yan WANG Hai-lin HAO Ran ZHAO Yong HUI Lian-qiang XIA Jing CAO Shuai LI Li-min and JI Shen |
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| Affiliation: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Shanghai Institute for Food and Drug Control, Shanghai 201203, China;Shanghai Institute for Food and Drug Control, Shanghai 201203, China;Shanghai Institute for Food and Drug Control, Shanghai 201203, China;Shanghai Institute for Food and Drug Control, Shanghai 201203, China |
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| Abstract: | |
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| Keywords: | realgar kidney toxicity pathology |
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