| 莲心碱对大鼠局灶性脑缺血C-Fos蛋白表达的影响 |
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| 引用本文： | 余万桂,陈庭煊,张恒文,谢平,张燕祥,张道明,刘莲,邓德明. 莲心碱对大鼠局灶性脑缺血C-Fos蛋白表达的影响[J]. 时珍国医国药, 2007, 18(3): 536-537 |
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| 作者姓名： | 余万桂 陈庭煊 张恒文 谢平 张燕祥 张道明 刘莲 邓德明 |
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| 作者单位： | 1. 长江大学医学院,湖北,荆州,434000
2. 湖北省荆州市第一人民医院,434000 |
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| 基金项目： | 湖北省卫生厅科研基金资助项目(No.JXzb74) |
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| 摘 要： | 目的观察莲心碱对大鼠局灶性脑缺血C-Fos蛋白表达的影响并探讨其保护作用机制。方法采用线栓法制备大鼠局灶性脑缺血模型,通过免疫组化法检测脑缺血24 h C-Fos蛋白的表达以及经莲心碱(3 mg/kg)处理后对该蛋白表达的影响。结果脑缺血24 h C-Fos蛋白的表达明显增加,莲心碱可显著抑制脑缺血后C-Fos蛋白表达。结论莲心碱的神经保护机制可能与抑制C-Fos蛋白的表达有关。
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| 关 键 词： | 莲心碱 脑缺血 C-Fos蛋白 |
| 文章编号： | 1008-0805（2007）03-0536-01 |
| 收稿时间： | 2006-08-01 |
| 修稿时间： | 2006-08-012006-12-01 |
Effect of Liensinine on C-Fos Protein Expression in Rats with Focal Cerebral Ischemia |
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| YU Wan-gui,CHENG Ting-xuan,ZHANG Hen-wen,XIE Ping,ZHANG Yang-xiang,ZHANG Dao-ming,LIU Lian,DENG De-ming. Effect of Liensinine on C-Fos Protein Expression in Rats with Focal Cerebral Ischemia[J]. Lishizhen Medicine and Materia Medica Research, 2007, 18(3): 536-537 |
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| Authors: | YU Wan-gui CHENG Ting-xuan ZHANG Hen-wen XIE Ping ZHANG Yang-xiang ZHANG Dao-ming LIU Lian DENG De-ming |
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| Affiliation: | 1.Medical School of Yangtze University , Jingzhou, Hubei 434000, China ; 2. First Hospltal of Jingzhou, Jingzhou, Hubei 434000, China |
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| Abstract: | ObjectiveTo observe the effect of liensinine on C-Fos protein expression in Rats with focal cerebral ischemia and investigate its protective mechanism.MethodsThe model of focal cerebral ischemia in rats was made by suture-occluded method,the expression of C-FOS protein and the effect of Liensinine(3mg/kg) applied prior ischemia on the expression were detected by immunohistochemical method after cerebral ischemia 24 h.ResultsThe expression of C-FOS protein significantly increased after 24 h ischemia and Liensinine significantly inhibited the expression of C-Fos.ConclusionThe protective mechanism of Liensinine is probably related to the inhibition of C-FOS gene expression. |
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| Keywords: | Liensinine Cerebral ischemia CFos Protein |
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