Two Cases of Bladder Carcinoma with Similar Initial Features That Exhibited Completely Different Clinical Courses

Two cases of bladder carcinoma are described. The patients wereof similar age, were both smokers and were treated for the sameperiod, but exhibited completely different later clinical courses.Initially, both had a single, papillary, pedunculate tumor,identified as a transitional cell carcinoma, grade 2. pTa. Onepatient, six years later, had multiple papillary tumors coveringalmost all the mucosal surface and underwent simple cystectomy.Histologically the tumors were identified as transitional cellcarcinomas, grade 2, pT1. The other patient, nine years later,had a single nodular invasive tumor with a concomitant, verytiny papillary tumor and underwent radical cystectomy. Histologicallythe tumor was transitional cell carcinoma, grade 2>3, pT4.Many of the questions raised by these cases are unanswered,but comparison of such cases should provide sonic cities tothe natural history of bladder carcinoma.