Metabolism of benzothiazole. I. Identification of ring-cleavage products. |
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Authors: | K Wilson H Chissick A M Fowler F J Frearson M Gittins F J Swinbourne |
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Institution: | School of Natural Sciences, Hatfield Polytechnic, Hertfordshire, UK. |
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Abstract: | 1. The metabolic fate of benzothiazole in guinea pig has been investigated following i.p. administration at a dose of 30 mg/kg. 2. Five ring-cleavage products were identified in urinary extracts by g.l.c.-mass spectra. By reference to authentic compounds the three major metabolites were shown to be 2-methylmercaptoaniline (I), 2-methylsulphinylaniline (II) and 2-methylsulphonylaniline (III). On the basis of the mass spectrometric evidence the remaining two metabolites were postulated to be 2-methylsulphinylphenylhydroxylamine (IV) and 2-methylsulphonylphenylhydroxylamine (V). 3. I, II and III were present in conjugated and unconjugated forms; IV and V were identified only after hydrolysis with sulphatase. |
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