2型糖尿病患者LP(a)水平与代谢综合征的关系

目的研究2型糖尿病患者LP(a)水平与伴发的代谢综合征组分相关性。方法采用横断面研究对上海地区1040例2型糖尿病患者进行了LP(a)水平的调查，同时采用Spearman单因素相关、Partial偏相关分析LP(a)与代谢综合征各组分的相关性，同时根据患者伴发代谢综合征组分数目分组，并对组间LP(a)水平进行统计分析。结果2型糖尿病患者LP(a)水平与尿微量白蛋白排泄率、血尿酸、空腹血糖及低密度脂蛋白胆固醇呈显著正相关性，而与胰岛素敏感指数呈显著负相关，但与肥胖、血压等无明显关联。同时LP(a)水平随着伴发代谢综合征组分数目的增加而明显升高。结论LP(a)水平与代谢综合征关系密切；监测2型糖尿病患者LP(a)水平有助于了解2型糖尿病患者伴发代谢综合征的情况；降低LP(a)水平有利于预防2型糖尿病患者慢性并发症的发生。

Relationships of Lipoprotein (a) with the Metabolic Syndrome in Type 2 Diabetes Mellitus

Purpose To examine the correlation between lipoprotein (a) [LP (a)] and members of metabolic syndrome in type 2 diabetes mellitus(DM). Methods We utilized cross-sectional study to investigate the level of LP (a) of 1040 patients with type 2 DM in Shanghai,and adopt spearman single-agent and partial correlation to analyze the correlation between LP (a) and metabolic syndrome in type 2 DM, then grouped the subjects according to magnitude of accompanying members of metabolic syndrome, and compared the significance of the level of LP (a) among groups. Results Level of LP (a) of patients with type 2 DM increased with the accretion of uric acid, urine albumin excretion, fasting glucose, low density lipoprotein, decreased with the promotion of insulin sensitivity. Moreover, the more the magnitude of accompanying members, the higher the level of LP (a) . Conclusions Intimate relationships existed between LP (a) and metabolic syndrome;detection of level of LP (a) of patients with type 2 DM might be conducive to determining the degree of metabolic syndrome. Lowering of LP (a) would benefit to prevent the occurrence of chronic complications of type 2 DM.