Comparative study of the effect of amiridine on biological membranes |
| |
| Authors: | Yu V Burov L V Tat'yanenko N V Kharakhonycheva T A Kondrat'eva T N Robakidze |
| |
| Institution: | (1) Russian Research Center for the Safety of Biologically Active Compounds, Moscow Region, Moscow, USSR |
| |
| Abstract: | The effects of amiridine and of the comparable drugs tacrine and piracetam on synaptosomes and membranes of sarcoplasmic reticulum
were studied by electron paramagnetic resonance; in addition, the effects of these drugs on the activity of Ca2+, Mg2+-dependent ATPase regulating calcium transport in neurons were investigated. In concentrations of 10−7 to 10−5 M the drugs did not affect the structure of synaptosomal membranes of rat brain. Amiridine and tacrine in a concentration
of 0.1 mM reduced the rate of calcium ion transport across the sarcoplasmic reticulum membrane by inhibiting the function
of Ca2+, Mg2+-dependent ATPase and induced marked changes of the structural rigidity of the protein part of the membrane.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N№ 11, pp. 503–505, November, 1995
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences |
| |
| Keywords: | amiridine tacrine piracetam synaptosomes sarcoplasmic reticulum Ca-ATPase |
| 本文献已被 SpringerLink 等数据库收录！ |
|
