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Comparative study of the effect of amiridine on biological membranes
Authors:Yu V Burov  L V Tat'yanenko  N V Kharakhonycheva  T A Kondrat'eva  T N Robakidze
Institution:(1) Russian Research Center for the Safety of Biologically Active Compounds, Moscow Region, Moscow, USSR
Abstract:The effects of amiridine and of the comparable drugs tacrine and piracetam on synaptosomes and membranes of sarcoplasmic reticulum were studied by electron paramagnetic resonance; in addition, the effects of these drugs on the activity of Ca2+, Mg2+-dependent ATPase regulating calcium transport in neurons were investigated. In concentrations of 10−7 to 10−5 M the drugs did not affect the structure of synaptosomal membranes of rat brain. Amiridine and tacrine in a concentration of 0.1 mM reduced the rate of calcium ion transport across the sarcoplasmic reticulum membrane by inhibiting the function of Ca2+, Mg2+-dependent ATPase and induced marked changes of the structural rigidity of the protein part of the membrane. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N№ 11, pp. 503–505, November, 1995 Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences
Keywords:amiridine                      tacrine                      piracetam                      synaptosomes                      sarcoplasmic reticulum Ca-ATPase
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