糖尿病患者感觉神经功能与下肢动脉病变的关系

目的 应用感觉神经测量仪(Neurometer)检测糖尿病(DM)患者周围感觉神经功能，并分析其与下肢动脉病变的关系。方法 测定100例DM患者的正中神经、腓肠神经于2000Hz、250Hz、5Hz时的电流感觉阈值，并作下肢动脉的彩色超声检查。结果 与正常对照组比较，DM患者电流感觉阈值明显升高，且有神经病变症状者较无症状者有显著性升高。74例行下肢动脉彩色超声检查者，31例有下肢动脉病变，其电流感觉阈值异常发生率较无下肢动脉病变组显著升高，且呈显著正相关。结论 DM患者的大、小神经纤维均受累，糖尿病神经病变(DPN)的发病可能与血管病变有关。

Sensory nerve function in diabetic patients and its relationship with lower extremity arterial disease

ObjectiveTo investigate the peripheral sensory f unction in diabetes mellitus with the neurometer and its relationship with lower extremity arterial disease in diabetic peripheral neuropathy.Methods One hundred diabetic patients and 30 healthy control subjects were in volved in the study. Using the Neurometer, current perception threshold testing at 2 000, 250 and 5 Hz was performed on median and peroneal nerves. Ultrasonic artery examination was taken on lower extremities.ResultsDia betic patients had increased current perception threshold at 2000Hz and 5Hz on b oth nerves as compared with the control group. Current perception threshold in t hose with neurological symptoms was higher than in asymptomatic patients. Of 74 patients who took up artery ultrasonic examination,31 patients had arterial dis ease. The rate of abnormal current perception threshold in those with lower extr emity arterial disease was higher than without lower extremity arterial disease , which was significantly corraletd with lower extremity arterial disease. ConclusionNot only large myelinated nerve but also small myelinate d or unmyelinated nerve may be involved in diabetes mellitus. Diabetic periphera l neuropathy may have vascular pathogenesis.