乙型肝炎后肝硬化血清leptin测定的临床意义分析

目的了解乙型肝炎后肝硬化患者血清瘦素（1eptin）水平变化的临床意义。方法选择诊断明确的乙肝后肝硬化患者60例，取同期健康体检者30例作为对照组。应用放射免疫法测定所有患者及对照组血清leptin水平，并检测肝功能及肝纤维化四项等项目；结果分析：采用SPSS11．5统计软件进行统计学处理，P〈0．05为差异有统计学意义。结果肝硬化组血清leptin水平明显高于对照组，P〈0．05；肝硬化失代偿期组比代偿期组血清leptin水平高，P〈0．05；肝硬化者Child—PughA级与c级组相比较，血清leptin水平有明显差异，P〈0．05，A级至C级组血清leptin水平逐渐升高。肝硬化组血清leptin水平与肝纤维化指标HA、C1V呈正相关，P〈0．05；结论血清leptin水平能够反映肝硬化患者肝脏炎症程度、肝功损害程度及肝纤维化活动程度。

Study on clinical significance of serum leptin level change in hepatocirrhosis

Objective To detect the clinical significance of serum leptin level change in hepatocirrhosis. Methods 60 cases of post hepatitis cirrhosis, meanwhile 30 cases of healthy medical examination were selected as control group ; serum leptin level of all the patients and control group were determined by radioimmunoassay, meanwhile liver function and four markers of liver fibrosis were detected; SPSS11.5 statistic software were adopted and One way analysis of variance（ANOVA） and pearson correlation analysis were carried out for statistic evaluation. Results Serum leptin level in hepatocirrhosis groups were higher than the control group, P 〈 0. 05 ; serum leptin level in decompensation stage of hepatocirrhosis was higher than compensation stage, P 〈 0.05 ; Serum leptin level of hepatocirrhosis in Child - Pugb A group had signgificant difference with C group, P 〈 0. 05. Serum leptin level gradually elevated from Child - Pugh A group to C group ; Serum leptin level in hepatocirrhosis group showed positive relationship with HA and C IV,P 〈 0. 05. Conclusions Serum leptin level could reflect the degree of liver inflammation and the damage degree of liver function and the degree of liver fihrotic activity in hepatocirrhosis.