An immunohistochemical evaluation of urinary bladder cytology using monoclonal antibodies |
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Authors: | K J M Panosian A Lopez-Beltran G A Croghan J F Gaeta M Gamarra |
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Institution: | (1) Department of Pathology, Roswell Park Memorial Institute, 666 Elm Street, 14263 Buffalo, NY, USA |
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Abstract: | Summary A total of 30 urinary bladder cytological specimens (urine and bladder washings) from 25 patients were reacted with a panel of 8 monoclonal antibodies predominantly derived from urinary bladder carcinoma, using avidin-biotin complex (ABC) immunohistochemical methodology. The clinical and epidemiological history of each of the patients evaluated was also revewed. A relatively high degree of sensitivity and specificity in the detection of malignancy was obtained in tests of urinary bladder cytological specimens with a combination of monoclonal antibodies. A role for monoclonal antibodies in the diagnosis of urinary bladder cytological specimens is discussed. |
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