非侵袭性与侵袭性基底细胞癌的VEGF表达及微血管密度的研究

目的：研究非侵袭性基底细胞癌（non-invasive basal cell carcioma,NIBCC）与侵袭性基底细胞癌（invasive basal cell carcionma,IBCC0的血管内皮生长因子（vascular endothelial growth factor,VEGF）的表达和肿瘤微血管密度（tumoral microvascular density,TMVD）,并探讨两者在BCC生物学行为中的意义。方法：应用免疫组化SP法检测34例BCC石蜡标本组织（17例非侵袭性,17例侵袭性）中的VEGF、Von-Willebrand因子表达。结果：在NIBCC与IBCC中,VEGF的表达水平中度且无明显统计学差异（P＝0.189）;IBCC的TMVD高于NIBCC（P＝0.019）;两者的TMVD、VEGF呈正相关（rsl=0.667,P=0.003;rs2=0.582,P=0.014）。结论：本实验中VEGF尚不能做为衡量BCC恶性度的指标,TMVD是衡量BCC侵袭性的较好指标之一。

The expression of vascular endothelial growth factor and the density of tumoral microvessels in non-invasive and invasive basal cell carcinoma

Objective:To investigate the expression of vascular endothelial growth factor (VEGF), the density of tumoral microvessels(TMVD), and their significance in non invasive basal cell carcinoma (NIBCC) and invasive basal cell carcinoma (IBCC).Methods:We used SP immunohistochemical staining for observing VEGF and Von Willebrand factor in NIBCC and IBCCs.Results: There were no statistically significant differences in the moderate level expression of VEGF between NIBCC and IBCC(P=0.189).The level of TMVD in IBCC was higher than that in NIBCC (P=0.019). The expression of VEGF was positively correlated both in NIBCC and IBCCs(r s1 = 0.667 ,P=0.003; r s2 =0.582,P=0.014). Conclusion :Based on this study VEGF might not be taken as an indicator of the malignancy in BCC, while TMVD is a good indicator in assessing the invasiveness of BCC. [