A study of the mechanism of action of befol on Ca2+ metabolism in cardiomyocytes using a FURA-2 fluorescent probe |
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| Authors: | P V Sergeev P A Galenko-Yaroshevskii A I Khankoeva A S Dukhanin |
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| Institution: | (1) Department of Molecular Pharmacology and Radiobiology, Russian State Medical University, Moscow;(2) Department of Pharmacology, Kuban Medical Academy, Krasnodar |
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| Abstract: | The dynamics of the Ca-response of cardiomyocytes is studied and the efficiency of befol, verapamil, and amiodarone is compared
using various experimental models of stimulation of Ca2+]i. Befol (1–5 μM) is shown to inhibit the caffeine-and strophanthin G-induced rise of Ca2+]i. Unlike verapamil and amiodarone, befol exhibits no Ca-blocking activity in modeled K-depolarization. It is concluded that
the cardiotropic effect of befol is mediated through its primary action on Na+/Ca2+ exchange in cardiomyocytes, while the cardioplegic effect of verapamil and amiodarone is due to their ability to block the
slow Ca2+ inward current.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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3, pp. 288–291, March, 1996 |
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| Keywords: | calcium befol amiloride strophanthin caffeine cardiomyocytes |
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