重症多形红斑型药疹25例和中毒性表皮坏死松解症17例回顾性分析

对1990年12月~2013年4月本院收治的25例重症多形红斑（SJS）和17例中毒性表皮坏死松解症（TEN）患者的临床资料进行回顾性分析。探讨SJS和TEN的致敏因素、发生规律、临床特征和治疗措施。药物是引起SJS和TEN的最主要病因。致敏药物以抗菌药物为主（52.38%），其次是抗癫痫药（28.57%）。黏膜损害和肝功能损害是最常见的并发症。 SJS和TEN均系统应用糖皮质激素治疗，SJS组8例和TEN组4例给予激素联合人免疫球蛋白治疗。系统应用糖皮质激素尤其是联合人免疫球蛋白治疗SJS和TEN有效。

A Retrospective Study on 25 Cases of Stevens Johnson Syndrome and 17 Cases of Toxic Epidermal Necrolysis

The clinical data of hospitalized patients of 25 cases of Stevens Johnson syndrome （SJS） and 17 cases of toxic epidermal necrolysis （TEN） were reviewed retrospectively from 1990 to 2013, to study the general patterns of the development of SJS and TEN, the clinical features and appropriate therapies. SJS and TEN had often been caused by drug reactions. The major sensitizing drugs were antibiotics （52.38%） and antiepileptics （28.57%）. Hepatitis and mucosal damage were the most common organ damage in both SJS and TEN. Systemic corticosteroids were used in 25 cases of SJS and 17 cases of TEN, among which 8 cases of SJS and 4 cases of TEN were treated with immunoglobulin combined with corticosteroid. Systemic therapy with corticosteroids especially treated with combined therapy of immunoglobulin and corticosteroid have beneficial effects on SJS and TEN.