儿童少年期精神分裂症患者听觉事件相关电位P300特征研究

目的探讨儿童少年期精神分裂症患者听觉事件相关电位P300(P300)的特征。方法随机选择年龄在6～15岁之间符合DSM-IV精神分裂症标准患者30例作为观察组,与观察组年龄、性别相匹配的健康者30例作为对照组。2组分别予P300检测,分别比较P300潜伏期、波幅及面积的差异。结果观察组PZ点潜伏期比对照组明显延长(t=2.977,P<0.01);观察组FZ、CZ、PZ、OZ点波幅比对照组降低(t=2.674、2.160、3.834、3.520,P<0.05或P<0.01)。观察组F3点波幅比F4点波幅降低(t=2.492,P<0.05)。结论儿童少年期精神分裂症患者存在认知功能损害,可能与大脑感知容量减低,半球间协调能力以及各脑区间整合能力下降有关。

Study on the character of auditory event-related potential P300 in childhood and adolescent schizophrenia

Objective To study the character of auditory event-related potential P300(P300) in childhood and adolescent schizophrenia.Methods Thirty patients(among 6~15 years old) with schizophrenia who were consistent with the diagnosis standard of DSM-IV for schizophrenia were enrolled as research group randomly and thirty healthy children whose age and sex were similar to the research group were selected as control group.Two groups were measured with P300.P300 latencies,amplitudes and areas of two groups were compared with each other respectively.Results PZ site latency in research group was longer than that in control group(t=2.977,P<0.01).FZ,CZ,PZ,OZ site amplitude in research group were lower than that in control group(t=2.674,2.160,3.834,3.520,P<0.05 or 0.01).F3 was lower than F4 in research group(t=2.492,P<0.05).Conclusion Childhood and adolescent schizophrenia patients present cognitive dysfunction,which may be responsible for the decline of patients′ cerebral cortical apperceive capacity and disability to perceptual organization of hemispheres and integration of cerebral areas.