Molecular genetics of Ca(2+) stores and intracellular Ca(2+) signalling. |
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Authors: | V Sorrentino R Rizzuto |
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Affiliation: | Molecular Medicine Section, Dept. of Neuroscience, University of Siena, via Aldo Moro 5, Siena 53100, Italy. |
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Abstract: | An increasing number of studies based on recombinant cells and on mouse models that express an altered repertoire of some of the key components of the intracellular Ca(2+) release stores are becoming available as a result of molecular genetics techniques. Information from these studies, together with results from studies of human diseases caused by mutations in genes that encode proteins of the intracellular Ca(2+) stores, are providing a significant advancement in understanding the interactive nature of the molecular machinery that underlies intracellular Ca(2+) signalling and how the different components of the Ca(2+) stores contribute to the regulation of cellular functions. |
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