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HPLC法测定注射用还原型谷胱甘肽含量
引用本文:张丽荣,王志刚,谢清毅. HPLC法测定注射用还原型谷胱甘肽含量[J]. 齐鲁药事, 2005, 24(2): 93-94
作者姓名:张丽荣  王志刚  谢清毅
作者单位:1. 烟台山医院,烟台,264001
2. 山东绿叶制药股份有限公司,烟台,264003
摘    要:目的 建立HPLC法测定注射用还原型谷胱甘肽含量。方法 采用HPLC法 ,色谱柱为DiscoverC18(2 5 0mm×4 6mm ,5 μm) ,流动相为磷酸盐溶液 -甲醇 (96∶4 ) ,流速为 1ml·min-1,检测波长为 2 10nm。结果 还原型谷胱甘肽在 1 2~7 2 μg范围内峰面积与进样量呈良好的线性关系。 结论 该法简便、准确 ,可作为该药品的含量测定方法

关 键 词:HPLC  还原型谷胱甘肽
文章编号:1672-7738(2005)02-0093-02

Determination of reduced glutathione for injection by HPLC
Zhang Li-rong,Wang Zhi-gang,Xie Qing-yi. Determination of reduced glutathione for injection by HPLC[J]. qilu pharmaceutical affairs, 2005, 24(2): 93-94
Authors:Zhang Li-rong  Wang Zhi-gang  Xie Qing-yi
Affiliation:Zhang Li-rong,Wang Zhi-gang1,Xie Qing-yi1
Abstract:Objective To determine reduced glutathione for injection by HPLC.Methods Discover?C 18column(250mm×4.6mm,5μm),with salt phosphate solution-methanol(96∶4)as mobile phase,flow rate was 1ml·min-1,and detection wavelength was 210nm.Results Reduced glutathione was separated well.It had good linearity in the range of 1.2~7.2μg.Conclusion This method was convenient and accurate.It can be used as the determination method of this drug.
Keywords:HPLC  reduced glutathione  
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