The use of sodium pentobarbital for the study of immobility-related (type 2) hippocampal theta |
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| Authors: | BH Bland RS Sainsbury M Seto BR Sinclair IQ Whishaw |
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| Institution: | Department of Psychology, The University of Calgary 2500 University Drive, Calgary, Alberta, Canada, T2N 1N4;Department of Psychology, The University of Lethbridge 4401 University Drive, Lethbridge, Alberta, Canada, TIK 3M4 |
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| Abstract: | A series of experiments investigated the effects of sodium pentobarbital on the dentate electroencephalographic (EEG) activity of rats and rabbits implanted with tungsten microelectrodes. Type 1 (movement-related) theta was abolished in both species and Type 2 (immobility-related) theta was abolished in the rat but remained intact and readily elicitable by sensory stimulation in the rabbit, following anaesthetic doses of pentobarbital. It was proposed that sodium pentobarbital may be useful for the investigation of mechanisms underlying the two types of theta and that the effect of pentobarbital provides further evidence for species differences in the way the hippocampal formation produces Type 2 theta. |
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| Keywords: | Sodium pentobarbital Hippocamal theta Immobility |
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