各型病毒性肝炎、肝癌抗－HCV检测及HCV感染与输血的关系

本文对各型病毒性肝炎、肝癌２００例进行血清抗－ＨＣＶ检测，阳性率为２０．５％，以重型肝炎和肝硬化检出率为高，分别为４２．８６％、４６．１５％，二者与其他型肝炎相比，有显著性差异（Ｐ＜０．０５）。输血后肝炎抗－ＨＣＶ阳性率为６７．５％，健康献血员抗－ＨＣＶ阳性率为２０．４７％，而输血后己型肝炎仅占２．５％。说明输血是造成丙型肝炎传播的重要途径，因此，对献血员应进行严格筛选。观察表明，ＨＢＶ与ＨＣＶ双重感染，可能是形成慢性肝炎，肝硬化以及促使肝炎向重型发展的重要原因之一。抗－ＨＣＶ阳性的慢性肝炎，血清ＡＬＴ５０％在正常范围内，余者仅轻度升高，说明ＨＣＶ感染所致的肝损伤可能是一个较慢的过程

The Anti-HCV Assay in Viral Hepatitisand Hepatoma and the Relationship between HCV Infection and Blood Transfusion

wo hundred cases of various kinds of viral hepatitis and hepatocellular carcinoma were test-ed for serum anti-HCV. The positive rates of anti-HCV in patients with severe hepatitis and patients with cirrhosis were 42.86%and 46.15%,respectively. They were significantly higher than those in patients with other kinds of hepatitis(P<0.05). The positive rate of anti-HCV was 67.5% in oatients with posttransfusion hepatitis,20.47% in healthv blood donors. In posttransfusion hepati-tis B it was only 2.5% Our results demonstrated that blood transfusion played an important role in transmitting HCV. Our findings also indicated that dual infec-tion of HBV and HCV was important in the course of chronic hepatitis,cirrhosis and severe hepatitis.50% of the anti-HCV positive patients with chronic hepatitis had slightly elevated serum alanine aminotransferase level.This showed that liver damage caused by HCV may be a chronic course.