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Brain deviations in adult obese-hyperglycemic mice (ob/ob) |
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| Authors: | Piet H.W. van der Kroon Gerrit J.A. Speijers |
| Affiliation: | Department of Zoology, Catholic University, Nijmegen, The Netherlands. |
| Abstract: | In the brain of adult obese-hyperglycemic mice (ob/ob) deviations, such as reduced brain weight, diminished myelination, and reduced amount of DNA were found. These findings cannot be explained by hypothyroidism in adults since above mentioned deviations could only have been caused by a reduced thyroidal activity in the first weeks of postnatal life. Therefore, our data are in support of the earlier hypothesis of congenital hypothyroidism. |
| Keywords: | Address reprint requests to Dr. G. J. A. Speijers National Institute of Public Health P.O. Box 1. Bilthoven The Netherlands. |
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