Factors affecting plasma amino acid concentrations in control subjects |
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Authors: | Judith P. Milsom Marsha Y. Morgan Sheila Sherlock |
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Affiliation: | Department of Medicine, The Royal Free Hospital, Pond Street, Hampstead, London, England. |
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Abstract: | Plasma amino acid concentrations were determined in groups of normal control subjects under fasting and postprandial conditions. Differences were observed that were found to be, to a considerable extent, sex-related. Fasting females had lower concentrations than fasting males of several amino acids, although postprandial differences in concentrations between the sexes were not significant. Under the dietary conditions normal for a British population, no significant diurnal variation of plasma amino acid concentrations was found. Reducing the dietary protein by 30% failed to affect plasma amino acid concentrations; however, increasing the dietary protein by 50% resulted in a significant increase in the plasma concentrations of several amino acids, and induced a significant degree of variation throughout the day in six, proline, half-cystine, methionine, valine, leucine, and isoleucine. The importance of these results with regard to the interpretation of population mean values and disease diagnosis is discussed. |
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Keywords: | Address reprint requests to Dr. J. P. Milsom Department of Medicine Royal Free Hospital Pond Street Hampstead London NW3 2QG England. |
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