慢性阻塞性肺疾病呼吸双相高分辨CT肺定量指标与肺功能相关性

目的探讨64排螺旋CT高分辨CT肺定量指标与肺功能检查各项指标的相关性及呼吸双相肺CT扫描对肺气肿的诊断价值。方法78例慢性阻塞性肺疾病患者分为轻度组8例，中度组28例，重度组26例与极重度组16例，4组均行呼吸双相全肺高分辨率CT检查，检测深吸气末、深呼气末肺密度、呼吸双相肺密度差及肺容积，分析肺密度与肺容积和肺功能各指标的相关性。结果4组深吸气末与深呼气末肺密度比较差异均有统计学意义（P〈0．05）；4组第1秒用力呼气量（forced expiratory volume in one second, FEV1 ）、用力肺活量（forced vital capacity, FVC）及FEV1／FVC比值比较差异均有统计学意义（P〈0．05）；随疾病严重程度增加，深吸气末与深呼气末肺容积均相应增加，但4组间比较差异均无统计学意义（P〉O．05）；胸部重建后深吸气末及深呼气末肺容积与FVC、FEV2、FEV1／FVC有明显相关性（P〈0．01）；深呼气末肺容积与残气量占最大肺总量百分比预计值间有明显相关性（P〈0．05）；深吸气相肺密度与FEV。／FVC、残气量值有明显相关性（P〈O．05）。结论64排螺旋CT呼吸双相高分辨率肺定量指标与肺功能测定具有良好相关性，可用于评价肺气肿严重程度。

Correlation between pulmonary quantitative indicators on high-resolution CT and pulmonary function in patients with chronic obstructive pulmonary disease

Objective To study the relationship between pulmonary quantitative indicators on 64-slice spiral CT and lung function, and the diagnosis value of breathing bipolar lung CT scan to emphysema. Methods Seventy-eight chronic obstructive pulmonary disease patients were divided into mild group （n= 8）, moderate group （n=28）, severe group （n=26） and gravely severe group （n= 16）. All these four groups received breathing bipolar total lung high-resolution CT scan to test lung density at the end of deep inspiration and expiration, breathing bipolar lung density difference and lung volume, and analyze the relationship between lung density/volume and lung function indicators. Results There were significant differences in lung density at the end of deep inspiration and expiration, the forced expiratory volume in one second （FEV1）, forced vital capacity （FVC） and FEV1/FVC among these four groups （P〈0.05）. The lung volume at the end of inspiration and expiration increased with the severity of disease, while there were no significant differences among these four groups （P〉0.05）. The lung volumes at the end of deep inspiration and expiration were obviously correlated with FVC, FEV1 and FEV1/FVC （P〈0.01）. The lung volume at the end of deep expiration was obviously correlated with the expected ratio of residual volume to maximum total lung capacity （P〈0.05）. The deep aspiratory phase lung density was closely correlated with FEV1/FVC and residual volume （P〈0.05）. Conclusion Pulmonary quantitative indicators on 64-slice spiral CT and pulmonary function has good correlation, and can be used to evaluate the severity of emphysema.